PAHO! partnered with the Ministry of Health of Guyana and the Ribeirão Preto College of Nursing at the University of São Paulo (PAHO/WHO Collaborating Center for Nursing Research Development) to conduct clinical simulation training exercises in Brazil. Participants included 21 nursing instructors from Antigua and Barbuda, Bahamas, Barbados, Grenada, Guyana, and Turks and Caicos. This highly effective training was implemented in the context of a South-South cooperation initiative that is currently redesigning the national curriculum for the professional education of registered nurses in Guyana.