As part of an initiative to improve the health of women and adolescents living in vulnerable conditions, and with support from Canada, PAHO collaborated with Honduras on a pilot telemedicine project in three communities located in the municipality of Trinidad. Significant benefits of the project include improvements in direct contact with users, increased access to care, and better quality of care for pregnant women, leading to greater trust in health care personnel and satisfaction with care. The project increased vaccination coverage for pregnant women with COVID-19, influenza, and tetanus toxoid vaccines. Health workers were also trained in use of the Perinatal Information System (SIP Plus) and in essential neonatal obstetric care. Telemedicine has the potential to improve access to quality services and is a key success factor in reaching better health outcomes.