As a specialized agency for global health in the Americas, the Pan American Health Organization (PAHO) is at the center of efforts to combat diseases, respond to emergencies and disasters, and strengthen regional health systems. To underscore efforts and amplify regional results in these areas, PAHO adopted an Organization-wide Results-Based Management (RBM) Framework in 2010. Given these strides towards a more comprehensive RBM of PAHO’s portfolio of work, the Organization conducted an assessment of its efforts to determine its achievements thus far. This report is the first of its kind – a comprehensive external evaluation of the RBM Framework for PAHO. It was commissioned to examine the implementation of RBM including its functioning, value added to the work of PAHO, and details around any improvements that could be made. The evaluation covered all four components of the RBM framework: Strategic and Operational Planning; Implementation, Performance Monitoring, and Assessment; Independent Evaluation and Learning; and Accountability; and considered the period from January 2008 to December 2022 within all levels of PAHO entities (regional, subregional, and country offices).